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KMID : 1155520090040030221
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Anesthesia and Pain Medicine
2009 Volume.4 No. 3 p.221 ~ p.225
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Subcutaneous botulinum toxin type a injection for chronic medial knee pain with ostheoarthritis
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Ahn Kang
Jhun Hyung-Joon
Lee Young-Jin
Kim Eun-Ha
Lim Tae-Kyun
Lee Sang-Chul
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Abstract
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Background: This study was designed to evaluate the efficacy of subcutaneous Botulinum toxin type A (BoNT-A) injection for treating chronic medial knee pain with osteoarthritis.
Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted at a university hospital in Korea.The subjects suffering from chronic medial knee pain with osteoarthritis were randomly allocated to either the BoNT-A (treatment, n = 23) group or the normal saline (placebo, n = 27) group.Injections were given to 10 points per unilateral knee along the course of the saphenous nerve.A total of 90 units of BoNT-A (60 units at baseline and 30 units after 1 week) was given for treating unilateral knee pain and a total of 180 units of BoNT-A was given for treating bilateral knee pain.The placebo group received the same volume of normal saline.
Results: The Visual Analog Scale (VAS) pain score was significantly decreased in both the BoNT-A and normal saline groups 1, 4 and 12 weeks after injection.After adjusting for covariates, BoNT-A had a 0.788 times higher effect to decrease the VAS score than did normal saline, but the effect was marginally significant (P = 0.050).
Conslusions: Subcutaneous injection along the course of the saphenous nerve significantly reduces chronic medial knee pain. The pain reduction effect of BoNT-A is higher than that of placebo, but the effect is marginally significant
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KEYWORD
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botulinum toxin, clinical trial, knee pain.
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